Jan. 11, 2023
In the two-plus years that COVID vaccines have been available in the U.S., the basic recipe has changed just once. But experts say SARS-CoV-2's evolutionary sprint might not be the only reason immunity can get bogged down. The body seems to fixate on the first version of the virus that it encountered, either through injection or infection – what researchers call "original antigenic sin." "I really, really hate that term," said Deepta Bhattacharya, an immunologist at the University of Arizona.