What older adults do while they sit affects dementia risk, study finds
Researchers explored the link between sedentary behavior and risk of dementia and found that type of activity matters when it comes to brain aging.
Adults ages 60 and older who sit for long periods watching TV or engaging in other passive, sedentary behaviors may be at increased risk of developing dementia, according to a new study by University of Arizona and University of Southern California researchers.
The study also showed that the risk is lower for those who are more active while sitting – engaging in behaviors like reading or using computers.
The study was published Monday in the journal Proceedings of the National Academy of Sciences.
"It isn't the time spent sitting, per se, but the type of sedentary activity performed during leisure time that impacts dementia risk," said lead study author David Raichlen, who was previously on the UArizona faculty and is now a professor of biological sciences and anthropology at USC.
"We know from past studies that watching TV involves low levels of muscle activity and energy use compared with using a computer or reading," Raichlen said. "And while research has shown that uninterrupted sitting for long periods is linked with reduced blood flow in the brain, the relatively greater intellectual stimulation that occurs during computer use may counteract the negative effects of sitting."
The study also revealed that the link between sedentary behavior and dementia risk persisted even among participants who were physically active.
"Although we know that physical activity is good for our brain health, many of us think that if we are just more physically active during the day, we can counter the negative effects of time spent sitting," said study co-author Gene Alexander, a professor in the UArizona Department of Psychology and Evelyn F. McKnight Brain Institute. "Our findings suggest that the brain impacts of sitting during our leisure activities are really separate from how physically active we are, and that being more mentally active, like when using computers, may be a key way to help counter the increased risk of dementia related to more passive sedentary behaviors, like watching TV."
Researchers used self-reported data from the UK Biobank, a large-scale biomedical database of more than 500,000 participants across the United Kingdom, to investigate possible correlations between sedentary, leisure activity and dementia in older adults.
More than 145,000 participants aged 60 and older – all of whom did not have a diagnosis of dementia at the start of the project – used touchscreen questionnaires to self-report information about their levels of sedentary behavior during the 2006-2010 baseline examination period.
After an average of nearly 12 years of follow-up, the researchers used hospital inpatient records to determine dementia diagnosis. They found 3,507 positive cases.
"Our ability to ask and answer these research questions is a testament to large-scale biomedical databases linked to medical records, such as the UK Biobank," said study co-author Yann Klimentidis, an associate professor of epidemiology and biostatics in the UArizona Mel and Enid Zuckerman College of Public Health. "They increasingly allow us to gain new insights into risk factors for dementia and many other diseases."
The team adjusted for certain demographics – such as a person's age, sex, race/ethnicity and employment type – and lifestyle characteristics – such as exercise, smoking, alcohol use, and time spent sleeping and engaging in social contact – that could affect brain health.
The results remained the same even after the scientists accounted for levels of physical activity. Even in individuals who are highly physically active, time spent watching TV was associated with an increased risk of dementia. In contrast, leisure-time spent using a computer was associated with a reduced risk of developing dementia.
"Our study shows that physical activity doesn't fully mitigate the risk of dementia from too much sitting in the same way it does for other diseases, however what we do while we're sitting matters," Raichlen said. "This knowledge is critical when it comes to designing targeted public health interventions aimed at reducing the risk of neurodegenerative disease from sedentary activities through positive behavior change."
In addition to Raichlen, Alexander and Klimentidis, other authors of the study include Pradyumna K. Bharadwaj of UArizona and M. Katherine Sayre, Mark H.C. Lai and Rand R. Wilcox of USC.
The study was supported by grants from the National Institutes of Health (P30AG072980, P30AG019610, R56AG067200, R01AG049464, R01AG72445), the state of Arizona and Arizona Department of Health Services, and the McKnight Brain Research Foundation.
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