The Wall Street Journal
Nov. 29, 2021
For COVID-19 vaccine doses, should there be more time between shots?
Two-dose vaccines are typically spaced months and sometimes years apart to provide long-lasting protection from disease. As children begin to get their COVID-19 shots, emerging research in adults suggests that waiting longer between doses could have similar benefits. The first COVID-19 shot generates memory B cells, which help fight infection. Over time, the stronger memory B cells survive while the weaker ones die, notes Deepta Bhattacharya, a professor of immunobiology at the University of Arizona College of Medicine – Tucson. A second shot bolsters that protection; if it happens later in the process, when the weaker cells have died, the shot will boost a stronger set of cells.