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The inactive form  of the MAPK p38 enzyme moves in an uncoordinated fashion. Once the necessary molecules  bind, the enzyme becomes active  by moving in a coordinated fashion to do its job inside a cell. 
(left) The inactive form of the MAPK p38 enzyme moves in an uncoordinated fashion. Once the necessary molecules bind, the enzyme becomes active by moving in a coordinated fashion to do its job inside a cell.