Bridi Graphical Abstract.jpg

Schematic comparison showing the brain of a fruit fly on the left and that of a mouse on the right, with homologous boundary in blue. Hirth Lab, King’s College London Schematic views of the developing brains of a fruit fly (left) and mouse (right). Areas shaded in blue show the deutocerebral-tritocerebral boundary in the fly and the midbrain-hindbrain boundary in the mouse. These homologous regions are shown here alongside shared expression patterns of homologous genes, indicated by the color patterns. In both organisms, the boundary gives rise to shared behavioral circuits that process sensory input, auditory and visual responses as well as balance and motor coordination, among others.